Age-Dependent Decline in the Coordinated [Ca(2+)] and Insulin Secretory Dynamics in Human Pancreatic Islets

Aging is associated with increased risk for type 2 diabetes, resulting from reduced insulin sensitivity and secretion. Reduced insulin secretion can result from reduced proliferative capacity and reduced islet function. Mechanisms underlying altered β-cell function in aging are poorly understood in...

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Veröffentlicht in:Diabetes
Hauptverfasser: Westacott, Matthew J., Farnsworth, Nikki L., St. Clair, Joshua R., Poffenberger, Greg, Heintz, Audrey, Ludin, Nurin W., Hart, Nathaniel J., Powers, Alvin C., Benninger, Richard K.P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2017
Schlagworte:
Islet Studies
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566297/
https://ncbi.nlm.nih.gov/pubmed/28588099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0137
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