Φορτώνει......
Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance.
The cardiac glycoside ouabain inhibits Na,K-ATPase by binding to the alpha subunit. In a highly ouabain resistant clone from the MDCK cell line, we have found two alleles of the alpha subunit in which the cysteine, present in the wild-type first transmembrane segment, is replaced by a tyrosine (Y) o...
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Κύριοι συγγραφείς: | , , , |
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Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
1992
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC556624/ https://ncbi.nlm.nih.gov/pubmed/1316269 |
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