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Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance.

The cardiac glycoside ouabain inhibits Na,K-ATPase by binding to the alpha subunit. In a highly ouabain resistant clone from the MDCK cell line, we have found two alleles of the alpha subunit in which the cysteine, present in the wild-type first transmembrane segment, is replaced by a tyrosine (Y) o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Canessa, C M, Horisberger, J D, Louvard, D, Rossier, B C
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1992
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC556624/
https://ncbi.nlm.nih.gov/pubmed/1316269
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