Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance.

The cardiac glycoside ouabain inhibits Na,K-ATPase by binding to the alpha subunit. In a highly ouabain resistant clone from the MDCK cell line, we have found two alleles of the alpha subunit in which the cysteine, present in the wild-type first transmembrane segment, is replaced by a tyrosine (Y) o...

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Bibliographic Details
Published in:EMBO J
Main Authors: Canessa, C M, Horisberger, J D, Louvard, D, Rossier, B C
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556624/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1316269/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05218.x
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