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Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance.
The cardiac glycoside ouabain inhibits Na,K-ATPase by binding to the alpha subunit. In a highly ouabain resistant clone from the MDCK cell line, we have found two alleles of the alpha subunit in which the cysteine, present in the wild-type first transmembrane segment, is replaced by a tyrosine (Y) o...
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Hlavní autoři: | , , , |
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Médium: | Artigo |
Jazyk: | Inglês |
Vydáno: |
1992
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Témata: | |
On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC556624/ https://ncbi.nlm.nih.gov/pubmed/1316269 |
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