Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits

NMDA-type glutamate receptors are ligand-gated ion channels that contribute to excitatory neurotransmission in the central nervous system (CNS). Most NMDA receptors comprise two glycine-binding GluN1 and two glutamate-binding GluN2 subunits (GluN2A–D). We describe highly potent (S)-5-[(R)-2-amino-2-...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lind, Genevieve E., Mou, Tung-Chung, Tamborini, Lucia, Pomper, Martin G., De Micheli, Carlo, Conti, Paola, Pinto, Andrea, Hansen, Kasper B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5565460/
https://ncbi.nlm.nih.gov/pubmed/28760974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707752114
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