Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.

In humans, trisomy 21 results in a specific phenotype known as Down syndrome (DS). The mechanism by which an extra copy of normal genes leads to the DS phenotype is unknown. Most studies in DS and other aneuploid organisms have shown that gene dose is proportional to gene expression. To date, most g...

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Bibliografiske detaljer
Main Authors: Holtzman, D M, Bayney, R M, Li, Y W, Khosrovi, H, Berger, C N, Epstein, C J, Mobley, W C
Format: Artigo
Sprog:Inglês
Udgivet: 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC556494/
https://ncbi.nlm.nih.gov/pubmed/1371464
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