SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.

Several cytoplasmic tyrosine kinases contain a conserved, non-catalytic stretch of approximately 100 amino acids called the src homology 2 (SH2) domain, and a region of approximately 50 amino acids called the SH3 domain. SH2/SH3 domains are also found in several other proteins, including phospholipa...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Rotin, D, Margolis, B, Mohammadi, M, Daly, R J, Daum, G, Li, N, Fischer, E H, Burgess, W H, Ullrich, A, Schlessinger, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556487/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1537335/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05087.x
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