The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

GRB2, a small protein comprising one SH2 domain and two SH3 domains, represents the human homologue of the Caenorhabditis elegans protein, sem-5. Both GRB2 and sem-5 have been implicated in a highly conserved mechanism that regulates p21ras signalling by receptor tyrosine kinases. In this report we...

Description complète

Détails bibliographiques

Publié dans:	EMBO J
Auteurs principaux:	Skolnik, E Y, Lee, C H, Batzer, A, Vicentini, L M, Zhou, M, Daly, R, Myers, M J, Backer, J M, Ullrich, A, White, M F
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 1993
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413414/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8491186/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05842.x
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!