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The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

GRB2, a small protein comprising one SH2 domain and two SH3 domains, represents the human homologue of the Caenorhabditis elegans protein, sem-5. Both GRB2 and sem-5 have been implicated in a highly conserved mechanism that regulates p21ras signalling by receptor tyrosine kinases. In this report we...

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Udgivet i:EMBO J
Principais autores: Skolnik, E Y, Lee, C H, Batzer, A, Vicentini, L M, Zhou, M, Daly, R, Myers, M J, Backer, J M, Ullrich, A, White, M F
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413414/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8491186/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05842.x
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