Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation

Overexpression of the GLI1 gene has frequently been found in various cancer types, particularly in brain tumors, in which aberrant GLI1 induction promotes cancer cell growth. Therefore, identifying the molecular players controlling GLI1 expression is of clinical importance. Previously, we reported t...

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Foilsithe in:Oncotarget
Main Authors: Zhang, Rui, Huang, Sherri Y., Ka-Wai Li, Kay, Li, Yen-Hsing, Hsu, Wei-Hsuan, Zhang, Guang Jun, Chang, Chun-Ju, Yang, Jer-Yen
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2017
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564814/
https://ncbi.nlm.nih.gov/pubmed/28562331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17769
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