The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-β antagonizing mechanism: attenuation of PACT-mediated RIG-I/MDA5 activation

Coronaviruses (CoVs) are a huge threat to both humans and animals and have evolved elaborate mechanisms to antagonize interferons (IFNs). Nucleocapsid (N) protein is the most abundant viral protein in CoV-infected cells, and has been identified as an innate immunity antagonist in several CoVs, inclu...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ding, Zhen, Fang, Liurong, Yuan, Shuangling, Zhao, Ling, Wang, Xunlei, Long, Siwen, Wang, Mohan, Wang, Dang, Foda, Mohamed Frahat, Xiao, Shaobo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564796/
https://ncbi.nlm.nih.gov/pubmed/28591694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17912
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