Co-targeting of IGF1R/mTOR pathway by miR-497 and miR-99a impairs hepatocellular carcinoma development

Persistent activation of IGF1R/mTOR signaling pathway plays crucial role in the development of hepatocellular carcinoma (HCC). Therefore, our goal was to elucidate microRNAs (miRNAs) targeting IGF1R/mTOR and the therapeutic potential of single or dual miRNA on HCC development. In this study, we foun...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Cheng, Henghui, Xue, Jin, Yang, Shouhua, Chen, Yaobin, Wang, Yu, Zhu, Yuanli, Wang, Xiaoyan, Kuang, Dong, Ruan, Qiurong, Duan, Yaqi, Wang, Guoping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564620/
https://ncbi.nlm.nih.gov/pubmed/28624790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18207
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