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Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation

Peripheral induction of regulatory T (Treg) cells provides essential protection from inappropriate immune responses. CD4(+) T cells that lack endogenous miRNAs are impaired to differentiate into Treg cells, but the relevant miRNAs are unknown. We performed an overexpression screen with T-cell-expres...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Warth, Sebastian C, Hoefig, Kai P, Hiekel, Anian, Schallenberg, Sonja, Jovanovic, Ksenija, Klein, Ludger, Kretschmer, Karsten, Ansel, K Mark, Heissmeyer, Vigo
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426480/
https://ncbi.nlm.nih.gov/pubmed/25712478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489589
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