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Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation

Peripheral induction of regulatory T (Treg) cells provides essential protection from inappropriate immune responses. CD4(+) T cells that lack endogenous miRNAs are impaired to differentiate into Treg cells, but the relevant miRNAs are unknown. We performed an overexpression screen with T-cell-expres...

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Dettagli Bibliografici
Pubblicato in:EMBO J
Autori principali: Warth, Sebastian C, Hoefig, Kai P, Hiekel, Anian, Schallenberg, Sonja, Jovanovic, Ksenija, Klein, Ludger, Kretschmer, Karsten, Ansel, K Mark, Heissmeyer, Vigo
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426480/
https://ncbi.nlm.nih.gov/pubmed/25712478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489589
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