Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer

PR domain zinc finger protein 14 (PRDM14) maintains stemness in embryonic stem cells via epigenetic mechanisms. Although PRDM14 is elevated in several cancers, it is unclear if and how PRDM14 confers stem cell-like properties and epigenetic changes to cancer cells. Here, we examined the phenotypic c...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Taniguchi, Hiroaki, Hoshino, Daisuke, Moriya, Chiharu, Zembutsu, Hitoshi, Nishiyama, Nobuhiro, Yamamoto, Hiroyuki, Kataoka, Kazunori, Imai, Kohzoh
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564528/
https://ncbi.nlm.nih.gov/pubmed/28423353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16776
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