Utilization of Optimal Study Design for Maternal and Fetal Sheep Propofol Pharmacokinetics Study: A Preliminary Study

Multiple blood samples are generally required for measurement of pharmacokinetic (PK) parameters. D-optimal design is a popular and frequently used approach for determination of sampling time points in order to minimize the number of samples, while optimizing the estimation of PK parameters. Optimal...

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Bibliographic Details
Published in:Curr Clin Pharmacol
Main Authors: Sherwin, Catherine M. T., Ngamprasertwong, Pornswan, Sadhasivam, Senthilkumar, Vinks, Alexander A.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564389/
https://ncbi.nlm.nih.gov/pubmed/24219004
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