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Three dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein.

The neu proto-oncogene may be converted into a dominantly transforming oncogene by a single point mutation. Substitution of a valine residue at position 664 in the transmembrane region with glutamic acid activates the tyrosine kinase of the molecule and is associated with increased receptor dimeriza...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gullick, W J, Bottomley, A C, Lofts, F J, Doak, D G, Mulvey, D, Newman, R, Crumpton, M J, Sternberg, M J, Campbell, I D
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1992
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC556423/
https://ncbi.nlm.nih.gov/pubmed/1346763
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