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Amplification of the proto-neu oncogene facilitates oncogenic activation by a single point mutation.

To determine whether the amplification of the proto-neu oncogene (also called c-erbB-2) plays a role in tumorigenicity, we previously generated an NIH 3T3 transfectant (DHFR/G-8) that carried the amplified proto-neu gene. The DHFR/G-8 cells exhibited normal morphology. Their growth curve was similar...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Hung, M C, Yan, D H, Zhao, X Y
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1989
Schlagworte:
Research Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286953/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2565034/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.8.2545
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