Amplification of the proto-neu oncogene facilitates oncogenic activation by a single point mutation.
To determine whether the amplification of the proto-neu oncogene (also called c-erbB-2) plays a role in tumorigenicity, we previously generated an NIH 3T3 transfectant (DHFR/G-8) that carried the amplified proto-neu gene. The DHFR/G-8 cells exhibited normal morphology. Their growth curve was similar...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1989
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286953/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2565034/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.8.2545 |
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