Amplification of the proto-neu oncogene facilitates oncogenic activation by a single point mutation.

To determine whether the amplification of the proto-neu oncogene (also called c-erbB-2) plays a role in tumorigenicity, we previously generated an NIH 3T3 transfectant (DHFR/G-8) that carried the amplified proto-neu gene. The DHFR/G-8 cells exhibited normal morphology. Their growth curve was similar...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Hung, M C, Yan, D H, Zhao, X Y
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286953/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2565034/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.8.2545
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!