Cancer-associated IDH1 promotes growth and resistance to targeted therapies in the absence of mutation

Oncogenic mutations in two isocitrate dehydrogenase (IDH)-encoding genes (IDH1 and IDH2) have been identified in acute myelogenous leukemia, low-grade glioma, and secondary glioblastoma (GBM). Our in silico and wet-bench analyses indicate that non-mutated IDH1 mRNA and protein are commonly overexpre...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Calvert, Andrea E., Chalastanis, Alexandra, Wu, Yongfei, Hurley, Lisa A., Kouri, Fotini M., Bi, Yingtao, Kachman, Maureen, May, Jasmine L., Bartom, Elizabeth, Hua, Youjia, Mishra, Rama K., Schiltz, Gary E., Dubrovskyi, Oleksii, Mazar, Andrew P., Peter, Marcus E., Zheng, Hongwu, James, C. David, Burant, Charles F., Chandel, Navdeep S., Davuluri, Ramana V., Horbinski, Craig, Stegh, Alexander H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564207/
https://ncbi.nlm.nih.gov/pubmed/28564604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.05.014
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