Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death

The unfolded protein response (UPR) is an endoplasmic reticulum (ER) -related stress conserved pathway that aims to protect cells from being overwhelmed. However, when prolonged, UPR activation converts to a death signal, which relies on its PERK-eIF2α branch. Overactivation of the UPR has been impl...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Louessard, Morgane, Bardou, Isabelle, Lemarchand, Eloïse, Thiebaut, Audrey M, Parcq, Jérôme, Leprince, Jérôme, Terrisse, Anne, Carraro, Valérie, Fafournoux, Pierre, Bruhat, Alain, Orset, Cyrille, Vivien, Denis, Ali, Carine, Roussel, Benoit D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563983/
https://ncbi.nlm.nih.gov/pubmed/28644439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.35
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