Synergistic Cytotoxicity from Drugs and Cytokines In Vitro as an Approach to Classify Drugs According to Their Potential to Cause Idiosyncratic Hepatotoxicity: A Proof-of-Concept Study

Idiosyncratic drug-induced liver injury (IDILI) typically occurs in a small fraction of patients and has resulted in removal of otherwise efficacious drugs from the market. Current preclinical testing methods are ineffective in predicting which drug candidates have IDILI liability. Recent results su...

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Foilsithe in:J Pharmacol Exp Ther
Main Authors: Maiuri, Ashley R., Wassink, Bronlyn, Turkus, Jonathan D., Breier, Anna B., Lansdell, Theresa, Kaur, Gurpreet, Hession, Sarah L., Ganey, Patricia E., Roth, Robert A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2017
Ábhair:
Toxicology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563944/
https://ncbi.nlm.nih.gov/pubmed/28687704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.242354
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