Myeloid-derived NF-κB negative regulation of PU.1 and cEBPβ-driven pro-inflammatory cytokine production restrains LPS-induced Shock

Sepsis is a life-threatening event predominantly caused by gram-negative bacteria. Bacterial infection causes a pronounced macrophage (MΦ) and dendritic cell (DC) activation that leads to excessive pro-inflammatory cytokine interleukin (IL)-1β, IL-6, and Tumor necrosis factor (TNF)-α production (cyt...

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Detalhes bibliográficos
Publicado no:Innate Immun
Main Authors: Vanoni, Simone, Tsai, Yi Ting, Waddell, Amanda, Waggoner, Lisa, Klarquist, Jared, Divanovic, Senad, Hoebe, Kasper, Steinbrecher, Kris A., Hogan, Simon P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563821/
https://ncbi.nlm.nih.gov/pubmed/27932520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1753425916681444
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