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The inhibitory mechanism of Hal3 on the yeast Ppz1 phosphatase: A mutagenesis analysis

The Ser/Thr protein phosphatase (PPase) Ppz1 is an enzyme related to the ubiquitous type-1 PPases (PP1c) but found only in fungi. It is regulated by an inhibitory subunit, Hal3, which binds to its catalytic domain. Overexpression of Ppz1 is highly toxic for yeast cells, so its de-regulation has been...

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Publicat a:Sci Rep
Autors principals: Molero, Cristina, Casado, Carlos, Ariño, Joaquín
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562863/
https://ncbi.nlm.nih.gov/pubmed/28821821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09360-5
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