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The inhibitory mechanism of Hal3 on the yeast Ppz1 phosphatase: A mutagenesis analysis

The Ser/Thr protein phosphatase (PPase) Ppz1 is an enzyme related to the ubiquitous type-1 PPases (PP1c) but found only in fungi. It is regulated by an inhibitory subunit, Hal3, which binds to its catalytic domain. Overexpression of Ppz1 is highly toxic for yeast cells, so its de-regulation has been...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Molero, Cristina, Casado, Carlos, Ariño, Joaquín
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562863/
https://ncbi.nlm.nih.gov/pubmed/28821821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09360-5
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