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The inhibitory mechanism of Hal3 on the yeast Ppz1 phosphatase: A mutagenesis analysis

The Ser/Thr protein phosphatase (PPase) Ppz1 is an enzyme related to the ubiquitous type-1 PPases (PP1c) but found only in fungi. It is regulated by an inhibitory subunit, Hal3, which binds to its catalytic domain. Overexpression of Ppz1 is highly toxic for yeast cells, so its de-regulation has been...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Molero, Cristina, Casado, Carlos, Ariño, Joaquín
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562863/
https://ncbi.nlm.nih.gov/pubmed/28821821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09360-5
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