Generation of a monkey with MECP2 mutations by TALEN-based gene targeting

Gene editing in model organisms has provided critical insights into brain development and diseases. Here, we report the generation of a cynomolgus monkey (Macaca fascicularis) carrying MECP2 mutations using transcription activator-like effector nucleases (TALENs)-mediated gene targeting. After injec...

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Detalhes bibliográficos
Publicado no:Neurosci Bull
Main Authors: Liu, Zhen, Zhou, Xue, Zhu, Ying, Chen, Zhi-Fang, Yu, Bin, Wang, Yan, Zhang, Chen-Chen, Nie, Yan-Hong, Sang, Xiao, Cai, Yi-Jun, Zhang, Yue-Fang, Zhang, Chen, Zhou, Wen-Hao, Sun, Qiang, Qiu, Zilong
Formato: Artigo
Idioma:Inglês
Publicado em: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2014
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562616/
https://ncbi.nlm.nih.gov/pubmed/24838303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-014-1434-8
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