Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys

Gene-editing technologies have made it feasible to create nonhuman primate models for human genetic disorders. Here, we report detailed genotypes and phenotypes of TALEN-edited MECP2 mutant cynomolgus monkeys serving as a model for a neurodevelopmental disorder, Rett syndrome (RTT), which is caused...

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Veröffentlicht in:Cell
Hauptverfasser: Chen, Yongchang, Yu, Juehua, Niu, Yuyu, Qin, Dongdong, Liu, Hailiang, Li, Gang, Hu, Yingzhou, Wang, Jiaojian, Lu, Yi, Kang, Yu, Jiang, Yong, Wu, Kunhua, Li, Siguang, Wei, Jingkuan, He, Jing, Wang, Junbang, Liu, Xiaojing, Luo, Yuping, Si, Chenyang, Bai, Raoxian, Zhang, Kunshan, Liu, Jie, Huang, Shaoyong, Chen, Zhenzhen, Wang, Shuang, Chen, Xiaoying, Bao, Xinhua, Zhang, Qingping, Li, Fuxing, Geng, Rui, Liang, Aibin, Shen, Dinggang, Jiang, Tianzi, Hu, Xintian, Ma, Yuanye, Ji, Weizhi, Sun, Yi Eve
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540256/
https://ncbi.nlm.nih.gov/pubmed/28525759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.04.035
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