TALEN-mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys

Recent advances in gene editing technology have introduced the potential for application of mutagenesis approaches in non-human primates to model human development and disease. Here we report successful TALEN-mediated mutagenesis of an X-linked, Rett Syndrome (RTT) gene, the methyl-CpG binding prote...

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Autors principals: Liu, Hailiang, Chen, Yongchang, Niu, Yuyu, Zhang, Kunshan, Kang, Yu, Ge, Weihong, Liu, Xiaojing, Zhao, Enfeng, Wang, Chencheng, Lin, Shaoyun, Jing, Bo, Si, Chenyang, Lin, Quan, Chen, Xiaoying, Lin, Haijun, Pu, Xiuqiong, Wang, Yingying, Qin, Binlian, Wang, Fang, Wang, Hong, Si, Wei, Zhou, Jing, Tan, Tao, Li, Tianqing, Ji, Shaohui, Xue, Zhigang, Luo, Yuping, Cheng, Liming, Zhou, Qi, Li, Siguang, Sun, Yi Eve, Ji, Weizhi
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024384/
https://ncbi.nlm.nih.gov/pubmed/24529597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.01.018
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