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Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin

NAD(P)H:quinone oxidoreductase 1 (NQO1) regulates the stability of the tumor suppressor WT p53. NQO1 binds and stabilizes WT p53, whereas NQO1 inhibitors including dicoumarol and various other coumarins and flavones induce ubiquitin-independent proteasomal p53 degradation and thus inhibit p53-induce...

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Библиографические подробности
Главные авторы: Tsvetkov, Peter, Asher, Gad, Reiss, Veronica, Shaul, Yosef, Sachs, Leo, Lotem, Joseph
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2005
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC556252/
https://ncbi.nlm.nih.gov/pubmed/15809436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501828102
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