A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

Execution of pluripotency requires progression from the naïve status represented by mouse embryonic stem cells (ESCs) to a state capacitated for lineage specification. This transition is coordinated at multiple levels. Non-coding RNAs may contribute to this regulatory orchestra. We identified a rode...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Li, Meng Amy, Amaral, Paulo P, Cheung, Priscilla, Bergmann, Jan H, Kinoshita, Masaki, Kalkan, Tüzer, Ralser, Meryem, Robson, Sam, von Meyenn, Ferdinand, Paramor, Maike, Yang, Fengtang, Chen, Caifu, Nichols, Jennifer, Spector, David L, Kouzarides, Tony, He, Lin, Smith, Austin
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
Assuntos:
Developmental Biology and Stem Cells
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562443/
https://ncbi.nlm.nih.gov/pubmed/28820723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23468
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