Autophagy was involved in the protective effect of metformin on hyperglycemia-induced cardiomyocyte apoptosis and Connexin43 downregulation in H9c2 cells

Background: Increased cardiomyocyte apoptosis under high glucose condition contributes to diabetic cardiomyopathy. Degradation of cardiac Connexin43 (Cx43) has been associated with cardiac dysfunction in diabetic heart. Clinical and experimental studies suggested that metformin (Met) exhibits cardio...

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Detalhes bibliográficos
Publicado no:Int J Med Sci
Main Authors: Wang, Guang-Yu, Bi, Ya-Guang, Liu, Xiang-Dong, Zhao, Yu, Han, Jun-Feng, Wei, Meng, Zhang, Qing-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562122/
https://ncbi.nlm.nih.gov/pubmed/28824303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijms.19800
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