Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway

Studies regarding macroautophagic/autophagic regulation in endothelial cells (ECs) under diabetic conditions are very limited. Clinical evidence establishes an endothelial protective effect of metformin, but the underlying mechanisms remain unclear. We aimed to investigate whether metformin exerts i...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Niu, Chao, Chen, Zhiwei, Kim, Kyoung Tae, Sun, Jia, Xue, Mei, Chen, Gen, Li, Santie, Shen, Yingjie, Zhu, Zhongxin, Wang, Xu, Liang, Jiaojiao, Jiang, Chao, Cong, Weitao, Jin, Litai, Li, Xiaokun
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526809/
https://ncbi.nlm.nih.gov/pubmed/30653446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1569913
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