PTEN regulates glutamine flux to pyrimidine synthesis and sensitivity to dihydroorotate dehydrogenase inhibition

Metabolic changes induced by oncogenic drivers of cancer contribute to tumor growth and are attractive targets for cancer treatment. Here, we found that increased growth of PTEN mutant cells was dependent on glutamine flux through the de novo pyrimidine synthesis pathway, which created sensitivity t...

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Detaylı Bibliyografya
Yayımlandı:Cancer Discov
Asıl Yazarlar: Mathur, Deepti, Stratikopoulos, Elias, Ozturk, Sait, Steinbach, Nicole, Pegno, Sarah, Schoenfeld, Sarah, Yong, Raymund, Murty, Vundavalli V., Asara, John M., Cantley, Lewis, Parsons, Ramon
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562025/
https://ncbi.nlm.nih.gov/pubmed/28255082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0612
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