Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii

The pyrimidine biosynthesis pathway in the protozoan pathogen Toxoplasma gondii is essential for parasite growth during infection. To investigate the properties of dihydroorotate dehydrogenase (TgDHOD), the fourth enzyme in the T. gondii pyrimidine pathway, we expressed and purified recombinant TgDH...

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Detalhes bibliográficos
Main Authors: Triana, Miryam Andrea Hortua, Huynh, My-Hang, Garavito, Manuel F., Fox, Barbara A., Bzik, David J., Carruthers, Vern B., Löffler, Monika, Zimmermann, Barbara H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855825/
https://ncbi.nlm.nih.gov/pubmed/22580100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2012.04.009
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