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Whole-protein Alanine-scanning Mutagenesis of Allostery: a Large Percentage of a Protein Can Contribute to Mechanism
Many studies of allosteric mechanisms use limited numbers of mutations to test whether residues play “key” roles. However, if a large percentage of the protein contributes to allosteric function, mutating any residue would have a high probability of modifying allostery. Thus, a predicted mechanism t...
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| Publié dans: | Hum Mutat |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5561450/ https://ncbi.nlm.nih.gov/pubmed/28407397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.23231 |
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