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Cooperative interaction of BMP signalling and Foxn1 gene dosage determines the size of the functionally active thymic epithelial compartment

Thymopoiesis strictly depends on the function of the Foxn1 transcription factor that is expressed in the thymic epithelium. During embryonic development, initial expression of the Foxn1 gene is induced in the pharyngeal endoderm by mesenchyme-derived BMP4 signals. Here, by engineering a time-delayed...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Swann, Jeremy B., Krauth, Brigitte, Happe, Christiane, Boehm, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561201/
https://ncbi.nlm.nih.gov/pubmed/28819138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09213-1
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