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Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes
Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein implicated in the pathogenesis of both familial and sporadic Parkinson’s disease (PD), and currently one of the most promising therapeutic targets for drug design in Parkinson’s disease. In contrast, LRRK1, the closest homologue to...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5561129/ https://ncbi.nlm.nih.gov/pubmed/28819229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09126-z |
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