Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein implicated in the pathogenesis of both familial and sporadic Parkinson’s disease (PD), and currently one of the most promising therapeutic targets for drug design in Parkinson’s disease. In contrast, LRRK1, the closest homologue to...

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Publicado no:Sci Rep
Main Authors: Sejwal, Kushal, Chami, Mohamed, Rémigy, Hervé, Vancraenenbroeck, Renée, Sibran, William, Sütterlin, Rosmarie, Baumgartner, Paul, McLeod, Robert, Chartier-Harlin, Marie-Christine, Baekelandt, Veerle, Stahlberg, Henning, Taymans, Jean-Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561129/
https://ncbi.nlm.nih.gov/pubmed/28819229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09126-z
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