Combined BRAF(V600E) and MEK blockade for BRAF(V600E)-mutant gliomas

BRAF(V600E) is a common finding in glioma (about 10–60% depending on histopathologic subclassification). BRAF(V600E) monotherapy shows modest preclinical efficacy against BRAF(V600E) gliomas and also induces adverse secondary skin malignancies. Here, we examine the molecular mechanism of intrinsic r...

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Bibliografiske detaljer
Udgivet i:J Neurooncol
Main Authors: Zhang, Jie, Yao, Tsun-Wen, Hashizume, Rintaro, Hariono, Sujatmi, Barkovich, Krister J., Fan, Qi-Wen, Prados, Michael, James, C. David, Weiss, William A., Nicolaides, Theodore
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560871/
https://ncbi.nlm.nih.gov/pubmed/27848137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-016-2333-4
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