Evolving Mistranslating tRNAs Through a Phenotypically Ambivalent Intermediate in Saccharomyces cerevisiae

The genetic code converts information from nucleic acid into protein. The genetic code was thought to be immutable, yet many examples in nature indicate that variations to the code provide a selective advantage. We used a sensitive selection system involving suppression of a deleterious allele (tti2...

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Bibliografiske detaljer
Udgivet i:Genetics
Main Authors: Berg, Matthew D., Hoffman, Kyle S., Genereaux, Julie, Mian, Safee, Trussler, Ryan S., Haniford, David B., O’Donoghue, Patrick, Brandl, Christopher J.
Format: Artigo
Sprog:Inglês
Udgivet: Genetics Society of America 2017
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Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560794/
https://ncbi.nlm.nih.gov/pubmed/28576863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.117.203232
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