HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes

Certain Major Histocompatibility-I (MHC-I) types are associated with superior immune containment of HIV-1 infection by CD8(+) cytotoxic T lymphocytes (CTLs), but the mechanisms mediating this containment are difficult to elucidate in vivo. Here we provide controlled assessments of fitness landscapes...

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Pubblicato in:PLoS Pathog
Autori principali: Gorin, Aleksandr M., Du, Yushen, Liu, Franklin Y., Zhang, Tian-Hao, Ng, Hwee L., Hofmann, Christian, Cumberland, William G., Sun, Ren, Yang, Otto O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560751/
https://ncbi.nlm.nih.gov/pubmed/28787455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006541
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