Determination of Methotrexate, 7-Hydroxymethotrexate, and 2,4-Diamino-N(10)-methylpteroic Acid by LC-MS/MS in Plasma and Cerebrospinal Fluid and Application in a Pharmacokinetic Analysis of High-Dose Methotrexate

A rapid and robust method for measuring methotrexate (MTX) and its two primary metabolites, 7-hydroxymethotrexate (7-OHMTX) and 2,4-diamino-N(10)-methylpteroic acid (DAMPA), was developed for use in pharmacokinetic studies of plasma and cerebrospinal fluid samples collected from infants with maligna...

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Detalhes bibliográficos
Publicado no:J Liq Chromatogr Relat Technol
Main Authors: Roberts, Michael S., Selvo, Nicholas S., Roberts, Jessica K., Daryani, Vinay M., Owens, Thandranese S., Harstead, K. Elaine, Gajjar, Amar, Stewart, Clinton F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560609/
https://ncbi.nlm.nih.gov/pubmed/28824272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10826076.2016.1243558
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