Blockade of PDGF receptors by crenolanib has therapeutic effect in patient fibroblasts and in preclinical models of systemic sclerosis

Systemic sclerosis (SSc) is a multi-organ fibrotic disease with few treatment options. Activated fibroblasts are the key effector cells in SSc responsible for the excessive production of collagen and the development of fibrosis. PDGF, a potent mitogen for cells of mesenchymal origin, has been implic...

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Publicado en:J Invest Dermatol
Autores principales: Makino, Katsunari, Makino, Tomoko, Stawski, Lukasz, Mantero, Julio C., Lafyatis, Robert, Simms, Robert, Trojanowska, Maria
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560111/
https://ncbi.nlm.nih.gov/pubmed/28433542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2017.03.032
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