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A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen

A genome-wide ethyl-N-nitrosourea (ENU) mutagenesis screen in mice was performed to identify novel regulators of erythropoiesis. Here, we describe a mouse line, RBC16, which harbours a dominantly inherited mutation in the Cpox gene, responsible for production of the haem biosynthesis enzyme, copropo...

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Dettagli Bibliografici
Pubblicato in:Dis Model Mech
Autori principali: Conway, Ashlee J., Brown, Fiona C., Fullinfaw, Robert O., Kile, Benjamin T., Jane, Stephen M., Curtis, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560062/
https://ncbi.nlm.nih.gov/pubmed/28600349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.029116
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