(CCUG)(n) RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis

The myotonic dystrophies are prototypic toxic RNA gain-of-function diseases. Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are caused by different unstable, noncoding microsatellite repeat expansions – (CTG)(DM1) in DMPK and (CCTG)(DM2) in CNBP. Although transcription of mutant repeats into (CUG)...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Yenigun, Vildan Betul, Sirito, Mario, Amcheslavky, Alla, Czernuszewicz, Tomek, Colonques-Bellmunt, Jordi, García-Alcover, Irma, Wojciechowska, Marzena, Bolduc, Clare, Chen, Zhihong, López Castel, Arturo, Krahe, Ralf, Bergmann, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560059/
https://ncbi.nlm.nih.gov/pubmed/28623239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.026179
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