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Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis
Dynamic processes are implicit in the catalytic function of all enzymes. To obtain insights into the relationship between the dynamics and thermodynamics of protein fluctuations and catalysis, we have measured millisecond time scale motions in the enzyme dihydrofolate reductase using NMR relaxation...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2005
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC556001/ https://ncbi.nlm.nih.gov/pubmed/15795383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500699102 |
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