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Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands
Enzyme catalysis can be described as progress over a multi-dimensional energy landscape where ensembles of interconverting conformational substates channel the enzyme through its catalytic cycle. We applied NMR relaxation dispersion to investigate the role of bound ligands in modulating the dynamics...
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| Päätekijät: | , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824364/ https://ncbi.nlm.nih.gov/pubmed/20080605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914163107 |
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