Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6 Inhibitor Discontinuation

Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer, developed rapid disease progression following discon...

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Publicado en:J Cancer
Autores principales: Bashour, Sami I., Doostan, Iman, Keyomarsi, Khandan, Valero, Vicente, Ueno, Naoto T., Brown, Powel H., Litton, Jennifer K., Koenig, Kimberly B., Karuturi, Meghan, Abouharb, Sausan, Tripathy, Debasish, Moulder-Thompson, Stacy L., Ibrahim, Nuhad K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559961/
https://ncbi.nlm.nih.gov/pubmed/28819400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.18196
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